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Mediators of Inflammation
Volume 2013 (2013), Article ID 479739, 8 pages
http://dx.doi.org/10.1155/2013/479739
Research Article

Resistin Regulates Pituitary Lipid Metabolism and Inflammation In Vivo and In Vitro

1Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
2CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Spain
3Endocrinology and Nutrition Service, Carlos Hayà Hospital, Fundación IMABIS, 29009 Málaga, Spain
4CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain
5Department of Cellular Biology, Physiology and Inmunology, School of Siences, University of Córdoba, Córdoba, Spain

Received 28 December 2012; Revised 21 March 2013; Accepted 21 March 2013

Academic Editor: Fabrizio Montecucco

Copyright © 2013 F. Rodriguez-Pacheco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism.