NF-𝜿B Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense

Figure 4

NF-𝜅B inhibition blocks lung injury and reduces apoptosis after CLP. (a) and (b) Histological evaluation of lung injury on H&E stained lung sections at 48 hours after CLP, *𝑃<0.05 for CLP versus sham laparotomy controls (Ctrl); ^#𝑃<0.05 for CLP+BMS versus CLP. (c) and (d) Lung edema as measured by wet/dry ratio at 24 and 48 hours after CLP, reported as increase above sham laparotomy controls. 𝑁=5 per group; *𝑃<0.05 for CLP+BMS versus CLP. Results are presented as mean ± SE.