Immunomodulation in Sepsis: The Role of Endotoxin Removal by Polymyxin B-Immobilized Cartridge
Table 1
Devices designed to remove endotoxin and cytokines in patients with septic shock.
Device
Company
Composition
Mechanism
Substance eliminated
Toraymyxin 20R
Toray Industries, Japan
Polymyxin B covalently bound to polypropylene-polystyrene fibers fabric
Adsorption
Endotoxin
LPS adsorber
Alteco Medical, Sweden
Synthetic polypeptide bound to porous polyethylene discs
Adsorption
Endotoxin
oXiris
Gambro-Hospal, France
AN69-based membrane, surface treated with a polyethyleneimine (PEI) and grafted with heparin
Adsorption Convection
Endotoxin Cytokines
MATISSE
Fresenius SE, Germany
Human serum albumin immobilised on polymethacrylate beads
Adsorption
Endotoxin
CPFA
Bellco, Italy
Polyethersulfone Plasma filter with adsorption on an unselective hydrophobicresin cartridge, and a synthetic high-permeability polyethersulfone hemofilter for continuous hemofiltration
Adsorption Plasma filtration
Cytokines
Cytosorb
Cytosorbents, USA
Polystyrenedivinyl benzene copolymer beads with a biocompatible polyvinylpyrrolidone coating.
