Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells

Figure 5

rSAA stimulates the production of relevant molecules in the tumor microenvironment. (a) rSAA (1 and 5 μg/mL) stimulates the production of IL-8 in a dose-dependent manner by A172 but not by T98G cells. (b) Dose dependence effect of rSAA (5 and 20 μg/mL) on O₂⁻ anion production as measured by lucigenin-enhanced chemiluminescence in gliomas. (c) SAA stimulates the production of NO in glioma cell lines even in lower concentrations. Data are mean ± SEM of three independent experiments. ^∗𝑃<0.05,^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 versus control. NO_𝑥—nitric oxide products.

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