Protective Effect of Short-Term Genistein Supplementation on the Early Stage in Diabetes-Induced Renal Damage

Table 2

Effect of genistein supplementation on biochemical markers.

Group	Lipid profiles				Kidney function		Oxidative stress
	TC; (mg/dL)	TG; (mg/dL)	HDL-C; (mg/dL)	AI	BUN; (mg/dL)	Creatinine; (mg/dL)	MDA; (nM)
CON	121.72±12.83^A	87.03±19.35^A	77.74±13.45	0.57±0.23^A	17.76±3.04^A	0.57±0.08^A	16.87±4.28^A
DMMH-C	187.98±21.15^B	119.89±26.92^AB	70.24±11.61	0.97±0.2^B	46.99±21.49^BCb	0.81±0.13^Bb	25.82±6.23^Bb
DMMH-0.025%	171.65±21.47	96.19±22.39	75.93±5.62	0.80±0.14	24.93±10.99^a	0.62±0.10^a	17.23±3.01^a
DMMH-0.1%	178.56±39.68	109.65±14.96	73.81±5.36	0.88±0.24	26.78±5.56^a	0.64±0.09^a	17.65±2.97^a
DMH-C	206.64±43.56^B	132.21±20.88^B	64.05±8.78	0.98±0.22^B	67.35±58.51^Cb	0.94±0.25^Cc	25.90±3.57^Bb
DMH-0.025%	172.29±45.89	107.71±29.20	73.83±15.64	0.93±0.23	32.30±10.68^a	0.72±0.11^ab	18.33±5.26^a
DMH-0.1%	173.32±46.33	121.43±35.15	71.10±29.38	0.94±0.41	32.78±7.95^a	0.79±0.21^bc	20.04±4.94^ab

Abbreviations: TC: total cholesterol, TG: triglyceride, HDL: high density lipoprotein cholesterol, AI: atherogenic index, BUN: blood urea nitrogen, and MDA: malondialdehyde.
Mean values with different letters were significantly different (𝑃<0.05). Statistical differences of variables among CON, DMMH-C, and DMH-C analyzed by one-way ANOVA were shown in capital letters and effects of the genistein supplemented diet and/or DM severity using two-way ANOVA were represented by small letters.