Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy

<table>Effect of 1,5-isoquinolinediol on retinal brain-derived neurotrophic factor (BDNF) expression in diabetes. The expression of BDNF in retinal homogenate was determined by Western blotting technique. The histogram represents the mean band intensity (from 6–8 rats in each group) of BDNF adjusted to the intensity of <i><i>β</i></i>-actin in the same sample. Values obtained from nondiabetic rats are considered as 100%. N: nondiabetic rat; D: diabetic rat; D + IQ: diabetic rat treated with 1,5-isoquinolinediol. <svg height="13.95" id="M8" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with diabetic rat.</table>

Mediators of Inflammation

fig3

Figure 3

Figure 3: Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy 