Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy

<table>Effect of 1,5-isoquinolinediol on retinal reactive oxygen species (ROS) levels in diabetes. Freshly prepared retinal homogenates were incubated with DCHFDA (5 <i><i>μ</i></i>M) for 30 min. An equal amount of protein was used to quantitate 2′,7′-dichlorofluorescein fluorescence. N: nondiabetic rat; D: diabetic rat; D + IQ: diabetic rat treated with 1,5-isoquinolinediol. Data are expressed as percent control and mean ± SD from retina from 5-6 rats in each group. <svg height="13.95" id="M16" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with nondiabetic rat. <svg height="15.775" id="M17" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 67.387497 15.775" width="67.387497" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> compared with diabetic rat.</table>

Mediators of Inflammation

fig7

Figure 7

Figure 7: Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy 