Increased Expression of VEGF and CD31 in Postradiation Rectal Tissue: Implications for Radiation Proctitis

Table 1

Histological findings in an individual patient at three time settings—before, at the completion of, and 6 months after radiotherapy.

	Before radiotherapy	At the completion of radiotherapy	6 months after radiotherapy
Patient 1	Normal	Mild active colitis-mild focal crypt atrophy-focal fibrosis	Mild nonspecific chronic inflammation
Patient 2	Normal	Focal fibrosis-mild crypt distortion	Mild nonspecific chronic inflammation-mucinophages
Patient 3	Normal	Focal fibrosis-mild focal crypt atrophy-thickening of the subepithelial collagen band	Mild nonspecific chronic inflammation-mild focal fibrosis-mucinophages
Patient 4	Normal	Focal fibrosis-mild focal crypt atrophy-thickening of the subepithelial collagen band	Mild nonspecific chronic inflammation
Patient 5	Normal	Mild active colitis	Mild nonspecific chronic inflammation-few mucinophages-focal fibrosis
Patient 6	Normal	Mild active colitis	Mild nonspecific chronic inflammation
Patient 7	Normal	Mild active colitis-few angiectasis	Mild nonspecific chronic inflammation
Patient 8	Normal	Mild active colitis-focal fibrosis	Thickening of the subepithelial collagen band-few mucinophages
Patient 9	Normal	Mild active colitis-thickening of the subepithelial collagen band	Focal crypt atrophy
Patient 10	Normal	Focal fibrosis-mild focal crypt atrophy-mild crypt distortion	Mild nonspecific chronic inflammation-few mucinophages
Patient 11	Normal	Mild crypt distortion	Focal fibrosis-thickening of the subepithelial collagen band