Persistent Inflammation in the CNS during Chronic EAE Despite Local Absence of IL-17 Production

Figure 2

Histopathological analysis of the CNS in C57BL/6 mice with EAE. Female mice were submitted to EAE induction by immunization with MOG emulsified in CFA. Inflammatory infiltrates were evaluated in brain (a, b, and c), cervical (d, e, and f), and lumbar (g, h, and i) spinal cord sections stained with H&E in control animals (a, d, and g) and in animals with EAE during acute (b, e, and h) and chronic disease stages (c, f, and i). Panel is representative of 6 animals/group.

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