Research Article

Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke

Table 2

Genotype and allele distributions of the IL-16 gene polymorphisms in IS cases and controls.

IS cases
(%)
Controls
(%)
Adjusted
OR (95% CI)
P value

rs4778889 T/C
Genotypes
 TT124 (62.6)138 (58.5)1.00
 TC66 (33.3)88 (37.3)0.56 (0.16–1.98)0.36
 CC8 (4.0)10 (4.2)0.94 (0.57–1.56)0.82
Alleles
 T314 (79.3)364 (77.1)1.00
 C82 (20.7)108 (22.9)0.93 (0.61–1.40)0.72

rs11556218 T/G
Genotypes
 TT88 (44.4)136 (57.6)1.00
 TG102 (51.5)94 (39.8)1.88 (1.15–3.07)0.01
 GG8 (4.0)6 (2.5)2.38 (0.63–9.05)0.20
Alleles
 T278 (70.2)366 (77.5)1.00
 G118 (29.8)106 (22.5)1.54 (1.05–2.27)0.03

rs4072111 C/T
Genotypes
 CC125 (63.1)141 (59.7)1.00
 CT63 (31.8)85 (36.0)0.62 (0.37–1.04)0.07
 TT10 (5.1)10 (4.2)1.38 (0.48–3.97)0.55
Alleles
 C313 (79.0)367 (77.8)1.00
 T83 (21.0)105 (22.2)0.76 (0.49–1.16)0.20

OR was adjusted for age, gender, hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia by binary logistic regression analysis.