Interleukin-16 Polymorphism Is Associated with an Increased Risk of Ischemic Stroke
Table 2
Genotype and allele distributions of the IL-16 gene polymorphisms in IS cases and controls.
IS cases (%)
Controls (%)
Adjusted OR (95% CI)
P value
rs4778889 T/C
Genotypes
TT
124 (62.6)
138 (58.5)
1.00
TC
66 (33.3)
88 (37.3)
0.56 (0.16–1.98)
0.36
CC
8 (4.0)
10 (4.2)
0.94 (0.57–1.56)
0.82
Alleles
T
314 (79.3)
364 (77.1)
1.00
C
82 (20.7)
108 (22.9)
0.93 (0.61–1.40)
0.72
rs11556218 T/G
Genotypes
TT
88 (44.4)
136 (57.6)
1.00
TG
102 (51.5)
94 (39.8)
1.88 (1.15–3.07)
0.01
GG
8 (4.0)
6 (2.5)
2.38 (0.63–9.05)
0.20
Alleles
T
278 (70.2)
366 (77.5)
1.00
G
118 (29.8)
106 (22.5)
1.54 (1.05–2.27)
0.03
rs4072111 C/T
Genotypes
CC
125 (63.1)
141 (59.7)
1.00
CT
63 (31.8)
85 (36.0)
0.62 (0.37–1.04)
0.07
TT
10 (5.1)
10 (4.2)
1.38 (0.48–3.97)
0.55
Alleles
C
313 (79.0)
367 (77.8)
1.00
T
83 (21.0)
105 (22.2)
0.76 (0.49–1.16)
0.20
OR was adjusted for age, gender, hypertension, diabetes mellitus, hypercholesterolemia, and hypertriglyceridemia by binary logistic regression analysis.