632049.fig.004a
(a) CD68
632049.fig.004b
(b) IRF5
632049.fig.004c
(c) YM1
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(d) IL-10
Figure 4: (a) HDM-exposed male ( ) and female ( ) mice had more CD68-positive cells in lung tissue as compared to control, but no differences were found between the HDM protocols. Combining all models, HDM exposure induced higher numbers of CD68-positive cells in females than in males ( ). (b) HDM-exposed male and female mice had more IRF5-positive cells in lung tissue as compared to control, but no differences were found between males and females when combining all models. The 14-day HDM protocol induced higher numbers of IRF5-positive cells as compared to the 24-day HDM protocol. (c) HDM-exposed male and female mice had more YM1-positive cells in lung tissue as compared to control, with higher numbers of YM1-positive cells in females than in males ( ). The 24-day HDM protocol induced higher numbers of YM1-positive cells as compared to the 14-day HDM protocol. (d) HDM-exposed male and female mice had lower numbers of IL-10-positive cells in lung tissue as compared to control, but no differences were found between the HDM protocols and between the sexes. The middle and right-hand panels are representative photos of control and HDM-exposed mice for all four stainings (magnification 200x). # , ## and ### compared to control. * .