- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Mediators of Inflammation
Volume 2013 (2013), Article ID 632049, 10 pages
Characterization of Macrophage Phenotypes in Three Murine Models of House-Dust-Mite-Induced Asthma
1Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
2GRIAC Research Institute, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
3Department of Pathology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
Received 12 October 2012; Accepted 11 January 2013
Academic Editor: Chiou-Feng Lin
Copyright © 2013 Christina Draijer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- P. J. Barnes, “Immunology of asthma and chronic obstructive pulmonary disease,” Nature Reviews Immunology, vol. 8, no. 3, pp. 183–192, 2008.
- G. P. Anderson, “Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease,” The Lancet, vol. 372, no. 9643, pp. 1107–1119, 2008.
- R. D. Stout and J. Suttles, “Functional plasticity of macrophages: reversible adaptation to changing microenvironments,” Journal of Leukocyte Biology, vol. 76, no. 3, pp. 509–513, 2004.
- D. M. Mosser and J. P. Edwards, “Exploring the full spectrum of macrophage activation,” Nature Reviews Immunology, vol. 8, no. 12, pp. 958–969, 2008.
- T. Krausgruber, K. Blazek, T. Smallie et al., “IRF5 promotes inflammatory macrophage polarization and T H1-TH17 responses,” Nature Immunology, vol. 12, no. 3, pp. 231–238, 2011.
- T. Kreider, R. M. Anthony, J. F. Urban Jr, and W. C. Gause, “Alternatively activated macrophages in helminth infections,” Current Opinion in Immunology, vol. 19, pp. 448–453, 2007.
- F. O. Martinez, L. Helming, and S. Gordon, “Alternative activation of macrophages: an immunologic functional perspective,” Annual Reviews, vol. 27, pp. 451–483, 2009.
- M. G. Nair, D. W. Cochrane, and J. E. Allen, “Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro,” Immunology Letters, vol. 85, no. 2, pp. 173–180, 2003.
- M. Peters-Golden, “The alveolar macrophage: the forgotten cell in asthma,” American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 1, pp. 3–7, 2004.
- A. P. Moreira and C. M. Hogaboam, “Macrophages in allergic asthma: fine-tuning their pro- and anti-inflammatory actions for disease resolution,” Journal of Interferon and Cytokine Research, vol. 31, no. 6, pp. 485–491, 2011.
- P. Dasgupta and A. D. Keegan, “Contribution of alternatively activated macrophages to allergic lung Inflammation: a tale of mice and men,” Journal of Innate Immunity, vol. 4, no. 5-6, pp. 478–488, 2012.
- M. Yang, R. K. Kumar, P. M. Hansbro, and P. S. Foster, “Emerging roles of pulmonary macrophages in driving the development of severe asthma,” Journal of Leukocyte Biology, vol. 91, pp. 557–569, 2012.
- Y. S. Chang, Y. K. Kim, J. W. Bahn et al., “Comparison of asthma phenotypes using different sensitizing protocols in mice,” Korean Journal of Internal Medicine, vol. 20, no. 2, pp. 152–158, 2005.
- A. T. Nials and S. Uddin, “Mouse models of allergic asthma: acute and chronic allergen challenge,” Disease Models and Mechanisms, vol. 1, no. 4-5, pp. 213–220, 2008.
- H. Hammad, M. Plantinga, K. Deswarte et al., “Inflammatory dendritic cells—not basophils—are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen,” The Journal of Experimental Medicine, vol. 207, pp. 2097–2111, 2010.
- L. G. Gregory, S. A. Mathie, S. A. Walker, S. Pegorier, C. P. Jones, and C. M. Lloyd, “Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25,” American Journal of Respiratory and Critical Care Medicine, vol. 182, no. 2, pp. 143–154, 2010.
- M. Arora, S. L. Poe, T. B. Oriss et al., “TLR4/MyD88-induced CD11b+F4/80+ non-migratory myeloid cells suppress Th2 effector function in the lung,” Mucosal Immunology, vol. 3, no. 6, pp. 578–593, 2010.
- M. J. Blacquière, W. Timens, B. N. Melgert, M. Geerlings, D. S. Postma, and M. N. Hylkema, “Maternal smoking during pregnancy induces airway remodelling in mice offspring,” European Respiratory Journal, vol. 33, no. 5, pp. 1133–1140, 2009.
- B. N. Melgert, T. B. Oriss, Z. Qi et al., “Macrophages: regulators of sex differences in asthma?” American Journal of Respiratory Cell and Molecular Biology, vol. 42, no. 5, pp. 595–603, 2010.
- B. N. Melgert, N. H. Ten Hacken, B. Rutgers, W. Timens, D. S. Postma, and M. N. Hylkema, “More alternative activation of macrophages in lungs of asthmatic patients,” Journal of Allergy and Clinical Immunology, vol. 127, no. 3, pp. 831–833, 2011.
- A. K. Abbas, A. H. Lichtman, and S. Pillai, Cellular and Molecular Immunology, Elsevier Saunders, Philadelphia, Pa, USA, 2011.
- G. Raes, P. de Baetselier, W. Noël, A. Beschin, F. Brombacher, and H. G. Gholamreza, “Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages,” Journal of Leukocyte Biology, vol. 71, no. 4, pp. 597–602, 2002.
- P. Loke, M. G. Nair, J. Parkinson, D. Guiliano, M. Blaxter, and J. E. Allen, “IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype,” BMC Immunology, vol. 3, article 7, 2002.
- J. S. Welch, L. Escoubet-Lozach, D. B. Sykes, K. Liddiard, D. R. Greaves, and C. K. Glass, “TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism,” Journal of Biological Chemistry, vol. 277, no. 45, pp. 42821–42829, 2002.
- K. R. B. Bastos, J. M. Alvarez, C. R. F. Marinho, L. V. Rizzo, and M. R. D. Lima, “Macrophages from IL-12p40-deficient mice have a bias toward the M2 activation profile,” Journal of Leukocyte Biology, vol. 71, pp. 271–278, 2002.
- A. Sindrilaru, T. Peters, S. Wieschalka et al., “An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice,” Journal of Clinical Investigation, vol. 121, no. 3, pp. 985–997, 2011.
- M. Nagata, “Inflammatory cells and oxygen radicals,” Current Drug Targets, vol. 4, no. 4, pp. 503–504, 2005.
- G. L. Chupp, C. G. Lee, N. Jarjour et al., “A chitinase-like protein in the lung and circulation of patients with severe asthma,” The New England Journal of Medicine, vol. 357, no. 20, pp. 2016–2027, 2007.
- M. Owhashi, H. Arita, and N. Hayai, “Identification of a novel eosinophil chemotactic cytokine (ECF-L) as a chitinase family protein,” Journal of Biological Chemistry, vol. 275, no. 2, pp. 1279–1286, 2000.
- N. C. A. Chang, S. I. Hung, K. Y. Hwa et al., “A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin,” Journal of Biological Chemistry, vol. 276, no. 20, pp. 17497–17506, 2001.
- D. Voehringer, N. van Rooijen, and R. M. Locksley, “Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages,” Journal of Leukocyte Biology, vol. 81, no. 6, pp. 1434–1444, 2007.
- M. M. Tiemessen, A. L. Jagger, H. G. Evans, M. J. C. van Herwijnen, S. John, and L. S. Taams, “CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 49, pp. 19446–19451, 2007.
- A. Q. Ford, P. Dasgupta, I. Mikhailenko, E. M. P. Smith, N. Noben-Trauth, and A. D. Keegan, “Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation,” BMC Immunology, vol. 13, articel 6, 2012.
- N. E. Nieuwenhuizen, F. Kirstein, J. Jayakumar et al., “Allergic airway disease is unaffected by the absence of IL-4Ra-dependent alternatively activated macrophages,” The Journal of Allergy and Clinical Immunology, vol. 130, no. 3, pp. 743.e8–750.e8, 2012.
- J. E. Korf, G. Pynaert, K. Tournoy et al., “Macrophage reprogramming by mycolic acid promotes a tolerogenic response in experimental asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 174, no. 2, pp. 152–160, 2006.
- C. Tang, M. D. Inman, N. van Rooijen et al., “Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-γ-dependent mechanism,” Journal of Immunology, vol. 166, no. 3, pp. 1471–1481, 2001.
- E. Goleva, P. J. Hauk, C. F. Hall et al., “Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages,” Journal of Allergy and Clinical Immunology, vol. 122, no. 3, pp. 550.e3–559.e3, 2008.
- N. H. T. Ten Hacken, Y. Oosterhoff, H. F. Kauffman et al., “Elevated serum interferon-γ in atopic asthma correlates with increased airways responsiveness and circadian peak expiratory flow variation,” European Respiratory Journal, vol. 11, no. 2, pp. 312–316, 1998.
- C. Wang, M. J. Rose-Zerilli, G. H. Koppelman et al., “Evidence of association between interferon regulatory factor 5 polymorphisms and asthma,” Gene Gene, vol. 504, pp. 220–225, 2012.
- I. Meyts, P. W. Hellings, G. Hens et al., “IL-12 contributes to allergen-induced airway inflammation in experimental asthma,” Journal of Immunology, vol. 177, no. 9, pp. 6460–6470, 2006.
- D. Bedoret, H. Wallemacq, T. Marichal et al., “Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice,” Journal of Clinical Investigation, vol. 119, no. 12, pp. 3723–3738, 2009.
- K. Maneechotesuwan, S. Supawita, K. Kasetsinsombat, A. Wongkajornsilp, and P. J. Barnes, “Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids,” Journal of Allergy and Clinical Immunology, vol. 121, no. 1, pp. 43–50, 2008.
- M. John, S. Lim, J. Seybold et al., “Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1α, granulocyte-macrophage colony-stimulating factor, and interferon-γ release from alveolar macrophages in asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 1, pp. 256–262, 1998.
- A. M. Fitzpatrick, M. Higgins, F. Holguin, L. A. S. Brown, and W. G. Teague, “The molecular phenotype of severe asthma in children,” Journal of Allergy and Clinical Immunology, vol. 125, no. 4, pp. 851.e18–857.e18, 2010.
- C. Almqvist, M. Worm, and B. Leynaert, “Impact of gender on asthma in childhood and adolescence: a GA 2LEN review,” Allergy, vol. 63, no. 1, pp. 47–57, 2008.
- B. N. Melgert, D. S. Postma, I. Kuipers et al., “Female mice are more susceptible to the development of allergic airway inflammation than male mice,” Clinical and Experimental Allergy, vol. 35, no. 11, pp. 1496–1503, 2005.
- B. N. Melgert, A. Ray, M. N. Hylkema, W. Timens, and D. S. Postma, “Are there reasons why adult asthma is more common in females?” Current Allergy and Asthma Reports, vol. 7, no. 2, pp. 143–150, 2007.