NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response
Figure 1
NAG-1 transgenic mice have a decreased inflammatory response to LPS. Seven- to twelve-week-old mice and wild-type littermates were injected with LPS (25 mg/kg i.p.). After 4 hours (a) and each time point (b), mice were sacrificed and serum was collected and analyzed for the level of cytokines and chemokines using a Multiplex system (Bio-Rad). Data were analyzed by nonparametric Mann-Whitney test (a) and ANOVA (b) to compare wild type to mice and are representative of two individual experiments.
