Review Article
Inflammasome in Intestinal Inflammation and Cancer
Table 1
Studies evaluating the role of the inflammasome in colitis-associated cancer using the AOM/DSS model.
| Mice model | Background | Impact on cancer | Description | Publication |
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IL-18−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Zaki et al. [7] Salcedo et al. [8] | IL-18R−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Salcedo et al. [8] | IL-1R−/− | C57BL/6 | No | No enhanced tumorigenesis | Salcedo et al. [8] | MyD88−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Salcedo et al. [8] | Caspase-1−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Zaki et al. [7] Allen et al. [9] Hu et al. [10] | ASC−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Zaki et al. [7] | Pycard−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Allen et al. [9] | NRRP-3−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Zaki et al. [7] Allen et al. [9] | NRRP-3−/− | C57BL/6 | No | No enhanced tumorigenesis | Hu et al. [10] | NLRC4−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Hu et al. [10] | NLRP-6−/− | C57BL/6 | Yes | Enhanced tumorigenesis | Chen et al. [11] Normand et al. [12] |
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