Review Article

Inflammasome in Intestinal Inflammation and Cancer

Table 1

Studies evaluating the role of the inflammasome in colitis-associated cancer using the AOM/DSS model.

Mice
model
BackgroundImpact on cancerDescriptionPublication

IL-18−/−C57BL/6YesEnhanced tumorigenesisZaki et al. [7]
Salcedo et al. [8]
IL-18R−/−C57BL/6YesEnhanced tumorigenesisSalcedo et al. [8]
IL-1R−/−C57BL/6NoNo enhanced tumorigenesisSalcedo et al. [8]
MyD88−/−C57BL/6YesEnhanced tumorigenesisSalcedo et al. [8]
Caspase-1−/−C57BL/6YesEnhanced tumorigenesisZaki et al. [7]
Allen et al. [9]
Hu et al. [10]
ASC−/−C57BL/6YesEnhanced tumorigenesisZaki et al. [7]
Pycard−/−C57BL/6YesEnhanced tumorigenesisAllen et al. [9]
NRRP-3−/−C57BL/6YesEnhanced tumorigenesisZaki et al. [7]
Allen et al. [9]
NRRP-3−/−C57BL/6NoNo enhanced tumorigenesisHu et al. [10]
NLRC4−/−C57BL/6YesEnhanced tumorigenesisHu et al. [10]
NLRP-6−/−C57BL/6YesEnhanced tumorigenesisChen et al. [11]
Normand et al. [12]