Minimally Modified LDL Upregulates Endothelin Type A Receptors in Rat Coronary Arterial Smooth Muscle Cells
Figure 5
Effect of the NF-κB pathway inhibitor on the mmLDL-induced upregulation of ETA receptors in the coronary artery. Rat coronary artery segments were cultured with mmLDL (10 μg/mL) in the presence of the NF-κB inhibitor wedelolactone (10 μM) for 24 h. The concentration-contraction curves mediated by the ETA receptor ((a) coronary arteries, the number of animals) and the levels of ETA receptor mRNA ((b) coronary arteries, from that number of animals) are shown. The data are presented as the mean ± SEM. versus mmLDL.
