Effects of ω-3 Polyunsaturated Fatty Acids on Plasma Proteome in Rett Syndrome
Figure 2
Plasma proteins expression as a function of ω-3 PUFAs supplementation in MECP2-mutated girls with classical RTT. (a) RTT patients before supplementation: expression levels are compared to healthy controls; (b) RTT patients after supplementation: expression levels are compared to untreated RTT; (c) RTT patients after supplementation: expression levels are compared to healthy controls. Data are expressed as box-and-whiskers plots. Box-and-whisker plots representation was used in a quite unconventional fashion. Our aim was to try to visually display relative changes in the expression of individual protein as compared to healthy controls. The variables represented correspond to relative changes: a value of 0 represents no changes in expression as compared to controls; positive values indicate protein overexpression, while negative values indicate protein underexpression. Significance of the changes were detected at ImageMaster analysis; therefore, this figure corresponds to a graphical device in order to visually detect the observed protein changes. Results of Kruskal-Wallis ANOVA are indicated. Asterisks in panel (c) indicates persistently overexpressed (top symbols) and persistently underexpressed proteins following ω-3 PUFAs supplementation as compared to control levels of expression.
