Structural domain organization and important posttranslational modifications of IRFs. Proteins are illustrated by N-terminus on the left and C-terminus on the right. Each of the nine IRFs consists of a conserved pentad repeat DNA-binding domain. Regulatory and repression domains are mostly located in the C-terminal domain. IRF-association domains 1/2(IADs) mediate the interaction with other IRF-family members. Yellow arrows indicate the phosphorylation site within the domain. Posttranslational modifications are illustrated in the right column. Numbers of amino acids for each IRF are given next to structural scheme.
