Working model of the role of interferon-regulatory factors in macrophage polarization. Circulating monocytes reach tissues by rolling and adhesion at luminal surfaces of activated endothelia, which is followed by transmigration into the interstitial tissue compartment. The local environment will prime M0 macrophage polarization, a process to which interferon-regulatory factors (IRFs) contribute in a phenotype-specific manner. See text for details.
