Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis

Figure 4

Collagen IV and ZO-1 mRNA expression. Spinal cords were harvested from treated and untreated EAE rats at day 17 p.i.; mRNA expression of collagen IV (a) and ZO-1 (b) was determined by RT-PCR, and an example of bands is shown. (c) Quantitative analysis. Results are expressed as mean ± SD (𝑛=8 each group). ^△△𝑃<0.01, compared to naive group; ^∗∗𝑃<0.01, compared to vehicle group; ^##𝑃<0.01, compared to DEX group; ^◊◊𝑃<0.01, comparison between MAT-L and MAT-H groups.

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