Inhibitory Effect of Matrine on Blood-Brain Barrier Disruption for the Treatment of Experimental Autoimmune Encephalomyelitis

Figure 6

Immunohistochemistry of MMP-2 and TIMP-2. At day 17 p.i., spinal cords were harvested after extensive perfusion. (a) MMP-2 and TIMP-2 expression was determined by immunohistochemistry. Magnification: ×40. (b) Quantitative analyses. Values represent mean ± SD (𝑛=8 each group). ^△△𝑃<0.01, compared to naive group; ^∗𝑃<0.05 and ^∗∗𝑃<0.01, compared to the vehicle group; ^#𝑃<0.05, compared to the DEX group; ^◊𝑃<0.05, comparison between MAT-L and MAT-H groups.

(a)

(b)