Proteinase-Activated Receptor-1 and Immunomodulatory Effects of a PAR1-Activating Peptide in a Mouse Model of Prostatitis
Figure 4
PAR1 is expressed in the wild-type mouse prostate. Prostates were treated with sterile saline and sacrificed 2 days posttreatment. PAR1 expression was localized via immunohistochemistry and was as follows. (a) Positive PAR1 staining throughout the apical acini epithelium (arrow), prostatic acini lumen (*), basal acini epithelium (dashed arrow), and prostatic epithelial cells (arrowhead) in wild-type mice. (b) Negative PAR1 staining in PAR1 knockout (PAR1−/−) mice. Sections were counterstained with hematoxylin; original magnification 100x.
