Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Figure 2

Measurements of liver injury. (a) Hepatic triglycerides were measured biochemically from C57BL/6J (B6), Nlrp3^−/−, and Nlrc4^−/− mice fed the ethanol-containing diet (EtOH-Fed) or pair-fed diet (Pair-Fed). (b) Plasma ALTs were measured with enzymatic assays from mice at the completion of the ethanol feeding trial. (c) NAFLD histological scores for steatosis and inflammation in B6, Nlrp3^−/−, and Nlrc4^−/−  mice. Values represent the mean ± SEM with **𝑃<0.01, ***𝑃<0.001 by Student’s 𝑡-test for 𝑛=4–6 mice per group. ND is abbreviation for NAFLD activity score of 0.

(a)

(b)

(c)