Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Figure 6

Hepatic expression of Nlrp3, Nlrc4, and Naip5 mRNA. RNA was isolated from C57BL/6J (B6), Nlrp3^−/−, and Nlrc4^−/− mice fed Lieber-DeCarli ethanol-containing diet (EtOH-Fed) or pair-fed controls (Pair-Fed). Expression of Nlrp3, Nlrc4, and Naip5 was measured. The values are the means ± SEM and normalized with 18S rRNA for 𝑛=4–6 mice per group. Values represent the mean ± SEM with **𝑃<0.05, ***𝑃<0.001 by Student’s 𝑡-test.