Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Figure 8

Increased caspase-3/7 in the liver of Nlrp3^−/− mice. Protein was isolated from C57BL/6J (B6), Nlrp3^−/−, and Nlrc4^−/− mice fed Lieber-DeCarli ethanol-containing diet (EtOH-Fed) or pair-fed controls (Pair-Fed). Expression of hepatic caspase-3/7 was measured as relative fluorescence. The values are the means ± SEM for 𝑛=4–6 mice per group. Values represent the mean ± SEM with **𝑃<0.05, ***𝑃<0.001 by Student’s 𝑡-test for 𝑛=4–6 mice per group.