An Anti-Inflammatory Sterol Decreases Obesity-Related Inflammation-Induced Insulin Resistance and Metabolic Dysregulation
Table 3
HE3286-0401 significant correlates of HbA1c and Hb changes.
Group
Dependent
Independent
Test
HE3286
Placebo
n
r
95% CI
P
n
r
95% CI
P
Cohort 1
ΔHbA1ca
MCP-1
Spearman
34
−0.42
−0.67 to −0.08
0.01
>0.10
ΔHOMA2 %B
Spearman
34
−0.43
−0.68 to 0.10
0.01
>0.10
ΔGlucose
Spearman
34
0.45
0.11 to 0.69
0.009
>0.10
ΔWeight
Spearman
34
0.45
0.13 to 0.69
0.007
>0.10
ΔHb
Pearson
34
0.36
0.03 to 0.62
0.03
>0.10
ΔHbA1c
TNF
Spearman
>0.10
34
−0.48
−0.71 to −0.16
0.004
ΔGlucose
Spearman
>0.10
38
0.65
0.41 to 0.81
<0.0001
ΔTNF
Spearman
>0.10
32
0.40
0.05 to 0.66
0.02
HbA1c CV
TNF
Pearson
>0.10
34
0.50
0.19 to 0.72
0.002
Cohort 2
ΔHbA1c
BMI
Spearman
25
−0.41
−0.70 to −0.008
0.04
>0.10
ΔHOMA2 %B
Pearson
25
−0.50
−0.75 to −0.13
0.02
>0.10
ΔGlucose
Pearson
25
0.61
0.29 to 0.81
0.001
>0.10
HbA1c CV
Hb CV
Pearson
>0.10
28
0.44
0.08 to 0.70
0.02
ΔMCP-1
Pearson
>0.10
20b
0.44
0.002 to 0.74
0.0495
ΔWeight
Pearson
>0.10
28
−0.43
−0.69 to −0.07
0.02
Hb CV
MCP-1
Spearman
>0.10
20
0.38
0.03 to 0.70
0.04
Cohort 2 BMI > 31
ΔnHbA1c
MCP-1
Spearman Exact
10b
−0.68
—c
0.03
>0.10
ΔMCP-1
Spearman Exact
9b
0.77
—
0.002
>0.10
aΔ: change in; CV: coefficient of variation; HbA1c: hemoglobin A1c; Hb: hemoglobin; MCP-1: monocyte chemoattractant protein-1; HOMA2 %B: homeostatic model assessment of pancreatic beta cell function; TNF: tumor necrosis factor alpha; BMI: body mass index; nHbA1c: HbA1c normalized to day 84 hemoglobin mass (see Section 2 for details). bMCP-1 data unavailable on a portion of participants. cSpearman Exact test has no confidence interval.