Collaborating with the Enemy: Function of Macrophages in the Development of Neoplastic Disease

Table 1

Macrophage subsets.

Populations	Inducing agents	Functions
	GM-CSF; IFN-γ + LPS; TNF-α	(i) High capacity for antigen presentation
		(ii) Th1 polarization
MI		(iii) Defense against bacteria
		(iv) Tumor suppression
		(v) Immunostimulation
		(vi) Ability to induce a cytotoxic effect
MII
MIIa	IL-4; IL-13	(i) Th2 polarization
MIIb	Immune complex;	(ii) Down-regulation of adaptive immunity
	IL-1R agonists; TLR ligands	(iii) Tumor growth promotion
MIIc	IL-10; TGF-β;	(iv) Proangiogenic
	glucocorticoids	(v) Tissue remodeling and repair