Prognostic Value of Inflammatory Mediators in 1-Year Outcome of Acute Ischemic Stroke with Middle Cerebral Artery Stenosis
Table 3
Univariate and multivariate analysis in patients’ 1-year outcome.
one-year mRS
value
OR (95% CI)
Multivariate value
0–2 (favorable),
3–6 (poor),
Age, years#
59.16 ± 11.02
62.23 ± 11.57
0.0002
1.022 (1.006–1.039)
0.0080
Male
526 (74.72)
173 (69.76)
0.1285
Duration between symptom onset to blood tests&, day
3 (1–5)
3 (1–5)
0.1990
Duration between symptom onset to MRI procedure&, day
6 (4, 8)
6 (4, 8)
0.1969
Previous mRS score
0.0002
—
—
0
588 (83.52)
178 (71.77)
1
92 (13.07)
51 (20.56)
2
24 (3.41)
19 (7.66)
History of, yes (, %)
Previous cerebral ischemia, TIA, ICH, or SAH
181 (25.71)
81 (32.66)
0.0351
—
—
Hypertension
561 (79.69)
207 (83.47)
0.1780
Diabetes mellitus
303 (43.04)
99 (39.92)
0.3922
Hyperlipidemia
589 (83.66)
193 (77.82)
0.0389
—
—
Current smoking
355 (50.43)
116 (46.77)
0.3226
Heavy-to-severe drinking
155 (22.02)
57 (22.98)
0.7530
Ischemic heart disease
81 (11.51)
20 (8.06)
0.1302
NIHSS score on admission&
3 (1, 6)
7 (3, 11)
<0.0001
1.063 (1.003–1.127)
0.0397
NIHSS score at discharge&
2 (0, 3)
5 (2, 9)
<0.0001
1.123 (1.045–1.208)
0.0017
MCA stenoocclusion
<0.0001
None or <50%
471 (66.90)
124 (50)
—
—
50–69%
173 (24.57)
90 (36.29)
1.708 (1.028–2.840)
0.0389
70%–99%
49 (6.96)
31 (12.50)
2.073 (1.107–3.882)
0.0228
100%
11 (1.56)
3 (1.21)
1.660 (1.066–2.585)
0.0249
Peripheral level of inflammatory mediators
WBC#, ×109/L
6.74 ± 1.87
7.38 ± 2.15
<0.0001
—
—
HCY#, μmol/L
17.45 ± 7.29
18.59 ± 7.39
0.0398
—
—
hs-CRP&, mg/L
2.0 (0.8, 5.75)
6.45 (1.9, 12.3)
<0.0001
1.060 (1.027–1.093)
0.0003
Other laboratory findings on admission
Hgb#, g/L
142.58 ± 17.36
140.69 ± 17.69
0.1450
PLT#, ×109/L
210.62 ± 55.36
218.53 ± 57.83
0.0577
1.004 (1.001–1.007)
0.0100
FBG#, mmol/L
5.91 ± 2.25
6.10 ± 2.13
0.2457
Cr#, μmol/L
79.43 ± 31.67
76.25 ± 23.18
0.0960
INR#
0.97 ± 0.07
0.99 ± 0.24
0.1911
HDL#, mmol/L
1.13 ± 0.28
1.11 ± 0.28
0.4684
LDL#, mmol/L
2.76 ± 0.85
2.77 ± 0.78
0.9366
#Continuous variables with normal distribution expressed as mean ± standard deviation.
&Continuous variables with nonnormal distribution expressed as interquartile range (IQR). Other values were expressed as (%). SAH: subarachnoid hemorrhage; ICH: intracerebral hemorrhage; NIHSS: National Institute of Health Stroke Scale; WBC: white blood cell; Hgb: hemoglobin; PLT: platelet; FBG: free blood glycemia; Cr: creatinine; INR: international normalized ratio; HCY: homocysteine; hs-CRP: high sensitivity C-reactive protein; HDL: high-density lipoprotein; and LDL: low-density lipoprotein.
