Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4 via PI3K/Akt Pathway in LPS-Induced Acute Lung Injury
Figure 1
Effects of lipoxin A4 on LPS-induced ALI. Lipoxin A4 (2 μg/kg) was administered intravenously to Sprague-Dawley (SD) rats 6 h after LPS (20 mL/kg) stimulation through the tail vein, and intratracheal instillation of 5% albumin solution containing Evans Blue-labeled albumin through a tracheostomy to the left lung, and ventilating for 1 hour. The right lung was isolated. The effect of lipoxin A4 was assessed by (a) histology in hematoxylin and eosin-stained sections, (b) histopathological scores, (c) the lung tissues homogenate TNF-α protein expression, and (d) the lung tissues homogenate IL-6 protein expression. Data were expressed as mean ± SEM for each group. * versus control group, # versus LPS group, for each group. LPS = lipopolysaccharide, LXA4 = lipoxin A4.
