Vitamin D Receptor Agonists Target CXCL10: New Therapeutic Tools for Resolution of Inflammation

Figure 2

CXCL10-CXCR3 axis. CXCL10 secreted by different types of organ-resident cells under IFN𝛾 induction is a potent chemoattractant for CXCR3-positive immune cells, in particular for activated T cells. T cell recruitment to sites of inflammation leads to an enhanced local increase of IFN𝛾, which, in turn, stimulates CXCL10 secretion by tissue cells; thus, a self-promoting inflammatory loop is established between resident and immune cells, making CXCL10-CXCR3 axis a therapeutic target for resolution of inflammation.