Vitamin D Receptor Agonists Target CXCL10: New Therapeutic Tools for Resolution of Inflammation

Table 2

In vivo effect of some VDR agonists. Vitamin D analogs suppress inflammatory mediators and processes resulting in disease prevention.

Disease	Analogs	Main in vivo effects	Reference
Type 1 diabetes	KH1060	Type I diabetes prevention without significant effects on calcium or bone metabolism	[95]
Autoimmune prostatitis	BXL-628	Inhibition of the intraprostatic inflammatory response	[96]
Interstitial cystitis	BXL-628	Reduction of mast cell degranulation	[97]
Heart and small bowel graft	MC-1288	Delay/prevention of graft rejection	[98]
Skin allograft	KH1060, CB966	Skin allograft survival prolongation	[99]
Collagen-induced arthritis (CIA)	MC-1288	CIA prevention and suppression	[100]
Inflammatory bowel disease	TX527	Reduction in mucosal damage and crypt loss and suppression of the infiltration of immune cells	[101]
Experimental autoimmune encephalomyelitis (EAE)	TX527	EAE prevention	[102]