Regulation of Immune Cell Infiltration into the CNS by Regional Neural Inputs Explained by the Gate Theory
Figure 4
Neural stimulation-mediated activation of the inflammation amplifier creates a gateway into the CNS via chemokine production. Schematic illustration of the tail suspension model (a). A string is fastened to the roof of the cage at a height that allows the forelimbs to support body weight but prevents the hindlimbs from touching any part of the cage. Release from gravitational stimuli caused by tail suspension (TS) results in a decrease of Ccl20 levels at the L5 dorsal venules. Electric stimulation (ES) during TS restores the levels in a time-dependent manner (b).
