The Role of T Cell Immunoglobulin Mucin Domains 1 and 4 in a Herpes Simplex Virus-Induced Behçet’s Disease Mouse Model

Figure 4

Administration of Tim-1 improved the Behçet’s disease (BD)-like symptoms, but the frequencies of Tim-1 expressing cells remained unchanged. Ten μg/mouse of Tim-1 vector was injected intraperitoneally four times at 2 day intervals into BD mice, followed by 2 weeks of observations. (a) Photographs of mice were taken before and at 1 and 2 weeks after the first treatment of the Tim-1 vector and control vector injected groups. (b) Severity scores were compared before and at 1 and 2 weeks after treatment. (c) Two weeks after first Tim-1 vector injection, the frequencies of Tim-1⁺, CD4⁺Tim-1⁺, CD8⁺Tim-1⁺, CD4⁺ T cells, and (d) Tim-4⁺ cells in LN and PBMCs were evaluated by FACS analysis (𝑛=5-6) (*𝑃<0.1). Con: control vector injection to BD mice, Tim-1: Tim-1 vector injection to BD mice.

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