The Role of T Cell Immunoglobulin Mucin Domains 1 and 4 in a Herpes Simplex Virus-Induced Behçet’s Disease Mouse Model

Figure 5

The frequencies of Treg cells in PBMCs were affected in Tim-1 vector injected Behçet’s disease (BD) mice. Two types of Treg cells were confirmed in LN and PBMCs after Tim-1 administration to BD mice. (a) The frequencies of CD4⁺CD25⁺, CD4⁺Foxp3⁺, and Treg cells were compared between the control and Tim-1 vector injected groups. Bottom panel shows CD4⁺CD25⁺ in PBMCs by FACS. (b) CD8⁺CD122⁺ T cells tended to be upregulated compared to those in the control group, but the difference was not significant. CD122⁺ cells increased significantly in the Tim-1 vector injected group (𝑛=5–8) (**𝑃<0.05, ***𝑃<0.01). Con: control vector injection to BD mice, Tim-1: Tim-1 vector injection to BD mice.

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(b)