The Role of T Cell Immunoglobulin Mucin Domains 1 and 4 in a Herpes Simplex Virus-Induced Behçet’s Disease Mouse Model
Figure 8
Behçet’s disease (BD)-like symptoms were changed after siTim-4 administration. Five μg/mouse of Tim-4 siRNA was injected intraperitoneally three times at 2 day intervals into BD mice and they were observed for 2 weeks. (a) Photographs of mice taken before and at 1 and 2 weeks after treatment with siTim-4 and the control treated group (Con: negative control siRNA treated groups). (b) The severity score was compared before and at 1 and 2 weeks after treatment between the siTim-4 and control treated groups. The frequencies of Tim-4+ cells in peritoneal cavity were compared between the siTim-4 and control treated groups. (c, d) The frequencies of Tim-4+, CD11b+Tim-4+, CD11c+Tim-4+, Tim-1+, CD4+Tim-1+, and CD8+Tim-1+ cells in LN were compared to the siTim-4 and control treated groups (-8) (**). Con: negative control injection to BD mice, siTim-4: Tim-4 siRNA injection to BD mice, LN: lymph node.
