Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Mn^IIMe₂DO2A on Experimental Articular Pain in Rats

Figure 6

Effect of 10⁻⁷M MnL4 on the lipid peroxidation (TBARS) induced by superoxide anion in human chondrocytes. Human chondrocytes were coincubated with RAW 264.7 with or without 10⁻⁷M MnL4. RAW 264.7 were activated by 10⁻⁷M fMLP for 4 h to produce superoxide anions. Values are expressed as percentage of control values (human chondrocytes coincubated with unstimulated RAW 264.7). TBARS in control value was 1.65±0.18𝜇 moles mg⁻¹ of total proteins. Each value represents the mean of 5 experiments, performed using chondrocytes isolated from 3 patients. *𝑃<0.05 versus all other conditions.