Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Mn^IIMe₂DO2A on Experimental Articular Pain in Rats

Table 1

Effect of MnL4 on hind limb weight bearing alterations induced by CFA or MIA.

Treatment	Δ Weight (g) (contralateral minus ipsilateral paw)
	0 min	15 min	30 min	45 min	60 min
Control (saline + saline)	5.2 ± 2.3	3.1 ± 1.9	3.8 ± 2.5	4.2 ± 3.0	6.3 ± 3.1
CFA + 15 mg kg^−1 MnL4	58.8 ± 1.6^∧ ∧	37.9 ± 2.1*	28.7 ± 1.9**	34.8 ± 2.0*	40.6 ± 2.3*
Control (saline + saline)	3.2 ± 1.2	−2.3 ± 2.1	1.5 ± 3.1	−3.0 ± 2.8	3.8 ± 2.5
MIA + 15 mg kg^−1 MnL4	61.3 ± 2.3^∧ ∧	30.2 ± 3.1*	20.1 ± 3.6**	40.3 ± 1.1*	55.3 ± 2.9

Hind limb weight bearing alterations were evaluated in rats by incapacitance test. In the absence of hind limb injury, rats applied an equal weight on both hind limbs, whereas an unequal distribution of the weight on hind limbs indicated a monolateral decreased pain threshold. CFA was injected 7 days before the test, MnL4 was acutely i.p. administered at time 0 min; MIA was injected 14 days before the test, MnL4 was acutely i.p. administered at time 0 min.
^∧∧𝑃  <  0.01 in respect to control (saline + saline) group; ^∗∗𝑃  <  0.01 and ^∗𝑃  <  0.05 with respect to the 0 min value of the same treatment.