Therapeutic Effects of the Superoxide Dismutase Mimetic Compound Mn^IIMe₂DO2A on Experimental Articular Pain in Rats

Table 2

TNFα plasma levels in control, MIA- and MnL4 + MIA-treated rats.

	Control (saline + saline)	Saline + MIA	MnL4 + MIA
pg/mL	5.37 ± 1.77	16.86 ± 2.02*	4.75 ± 1.69

Monoiodoacetate (MIA, 2 mg/25 µL) or saline was injected in the left posterior tibiotarsal articulation 14 days before the test. At day 0, a minipump containing MnL4 solution (15 mg kg⁻¹ day) was implanted on the back of MnL4 + MIA-treated rats. TNFα levels were measured in plasma samples by ELISA.
^∗𝑃  <  0.01 versus saline + saline and the MnL4 + MIA groups.