Differential IL-13 Production by Small Intestinal Leukocytes in Active Coeliac Disease versus Refractory Coeliac Disease
Table 1
Patient characteristics and composition of leucocyte infiltrates.
ACD
GFD
RCDII
Sex, % females
75.0%
71.4%
33.3%
Age, yrs
45.8 (22.2–75.3)
55.9 (35.3–72.0)
70.6 (41.7–76.2)
Villous atrophy, %
100%
0.0%
45.5%
Cell yield, 103 IEL/biopsy
28.5 (7.5–58.0)
16.0 (2.1–113.0)
19.1 (5.8–62.4)
CD3+ IEL, % of CD45
99 (97–99)
96 (86–98)
21 (10–99)*
CD4+ IEL, % of CD45
5 (1–10)
3 (2–32)
5 (1–14)
CD8+ IEL, % of CD45
77 (59–86)
78 (65–90)
13 (5–69)*
CD16/56+ IEL, % of CD45
1 (0–3)
2 (1–11)
3 (0–24)
Aberr. IEL, % of CD45
0 (0-1)
2 (0–6)
66 (1–87)*
CD3+ LPL, % of CD45
40–43
21–60
25–38
CD4+ LPL, % of CD45
13–28
0–31
8–24
CD8+ LPL, % of CD45
10–16
2–29
4–14
CD16/56+ LPL, % of CD45
3-3
5–8
1–4
CD19+ LPL, % of CD45
4-5
1–8
3–10
For age and IEL data medians (5 percentile–95 percentile) are shown. For LPL data ranges are shown, since data for composition of LPL was available only in 2 ACD patients, 4 GFD patients, and 4 RCDII patients.
*Significantly lower percentage of CD3+ and CD8+ cells compared to ACD and GFD (due to high percentage of aberrant T-cells).
