Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes

<table>Heme induces a proinflammatory profile in AM. Heme induces NADPHox-dependent ROS production and NF-<i>κ</i>B nuclear translocation. These processes can be directly related to NO production, phagocytosis, killing, and cytokine release, functions that are involved in the inflammatory response induced by heme.</table>

Mediators of Inflammation

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Figure 8

Figure 8: Proinflammatory Responses of Heme in Alveolar Macrophages: Repercussion in Lung Hemorrhagic Episodes 