Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection

Figure 6

Treatment with celecoxib alters cytokine concentrations in the lung tissue of infected mice. The lungs were removed at 2, 14, and 28 days after i.t. inoculation and oral treatments and homogenized in medium. IL-1 (a), IL-6 (b), KC (c), TNF-α (d), IL-10 (e), IL-12 (f), and IFN-γ (g) concentrations were determined using ELISA. The data are presented as the means ± SEM representative of three independent experiments (𝑛=5-6). One-way ANOVA (Tukey's multiple comparison test) was used. *PBS + H₂O versus Hc + H₂O; ^#Hc + H₂O versus Hc + celecoxib 𝑃<0.05.

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