Review Article
Interleukin-17 Gene Polymorphisms Contribute to Cancer Risk
Table 2
Summary of ORs and 95% CI of IL-17A rs2275913G>A and IL-17F rs763780T>C polymorphisms and cancer risk.
| | N
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| A versus G | GA versus GG | AA versus GG | GA + AA versus GG | AA versus GG + GA | OR | 95% CI | P | (%)a | OR | 95% CI | P | (%)a | OR | 95% CI | P | (%)a | OR | 95% CI | P | (%)a | OR | 95% CI | P | (%)a |
| Total | 10 | 1.28 | 1.16–1.41 | <0.001 | 61.1 | 1.12 | 1.02–1.23 | 0.015 | 27.8 | 1.71 | 1.38–2.14 | <0.001 | 69.6 | 1.23 | 1.13–1.34 | <0.001 | 6.4 | 1.62 | 1.27–2.07 | <0.001 | 81.4 | HWE | 8 | 1.26 | 1.13–1.41 | <0.001 | 66.4 | 1.15 | 1.04–1.27 | 0.008 | 0 | 1.63 | 1.29–2.08 | <0.001 | 70 | 1.23 | 1.12–1.36 | <0.001 | 9.7 | 1.51 | 1.18–1.93 | 0.001 | 78.4 | Ethnicity | | | | | | | | | | | | | | | | | | | | | | Asian | 9 | 1.25 | 1.14–1.37 | <0.001 | 56.5 | 1.12 | 1.02–1.23 | 0.019 | 35.6 | 1.65 | 1.32–2.05 | <0.001 | 68.6 | 1.22 | 1.12–1.33 | <0.001 | 4.4 | 1.55 | 1.21–1.99 | 0.001 | 81.6 | China | 7 | 1.21 | 1.10–1.34 | <0.001 | 56.2 | 1.19 | 1.07–1.32 | 0.001 | 0 | 1.46 | 1.20–1.79 | <0.001 | 54.3 | 1.24 | 1.13–1.37 | <0.001 | 14.9 | 1.30 | 1.09–1.56 | 0.004 | 56.6 | Design | | | | | | | | | | | | | | | | | | | | | | PB | 4 | 1.16 | 1.01–1.32 | 0.031 | 63.3 | 1.14 | 1.01–1.29 | 0.041 | 0 | 1.34 | 1.02–1.76 | 0.033 | 65 | 1.18 | 1.05–1.32 | 0.006 | 1.1 | 1.23 | 0.96–1.59 | 0.108 | 69.7 | HB | 5 | 1.35 | 1.23–1.48 | <0.001 | 0 | 1.10 | 0.87–1.39 | 0.447 | 63.1 | 1.97 | 1.64–2.37 | <0.001 | 0 | 1.28 | 1.12–1.46 | <0.001 | 11.8 | 1.87 | 1.38–2.52 | <0.001 | 69.2 | Location | | | | | | | | | | | | | | | | | | | | | | Gastric | 7 | 1.26 | 1.11–1.44 | <0.001 | 70 | 1.07 | 0.96–1.19 | 0.202 | 24.2 | 1.70 | 1.26–2.30 | 0.001 | 77.8 | 1.18 | 1.06–1.30 | 0.001 | 0 | 1.67 | 1.18–2.36 | 0.004 | 87 | Others | 3 | 1.33 | 1.19–1.49 | <0.001 | 0 | 1.27 | 1.05–1.53 | 0.013 | 6.6 | 1.81 | 1.43–2.29 | <0.001 | 0 | 1.39 | 1.18–1.65 | <0.001 | 0 | 1.56 | 1.27–1.91 | <0.001 | 0 |
| | | C versus T | TC versus TT | CC versus TT | TC + CC versus TT | CC versus TT + TC |
| Total | 7 | 1.09 | 0.91–1.30 | 0.347 | 64.6 | 1.06 | 0.84–1.34 | 0.629 | 70 | 1.33 | 1.02–1.75 | 0.038 | 0 | 1.08 | 0.87–1.35 | 0.486 | 70.3 | 1.26 | 0.96–1.65 | 0.098 | 0 | HWE | 4 | 0.95 | 0.81–1.10 | 0.516 | 46.4 | 0.92 | 0.71–1.19 | 0.650 | 57.2 | 1.15 | 0.61–2.17 | 0.660 | 0 | 0.93 | 0.72–1.19 | 0.557 | 55.5 | 1.18 | 0.62–2.21 | 0.616 | 0 | Ethnicity | | | | | | | | | | | | | | | | | | | | | | China | 6 | 1.08 | 0.88–1.33 | 0.439 | 70.4 | 1.06 | 0.81–1.39 | 0.676 | 74.7 | 1.32 | 1.00–1.74 | 0.053 | 0 | 1.08 | 0.84–1.39 | 0.555 | 75.1 | 1.24 | 0.94–1.63 | 0.130 | 0 | Design | | | | | | | | | | | | | | | | | | | | | | PB | 3 | 1.29 | 1.13–1.41 | <0.001 | 32.4 | 1.34 | 1.14–1.57 | <0.001 | 43.4 | 1.40 | 1.01–1.96 | 0.045 | 0 | 1.34 | 1.05–1.57 | <0.001 | 45.8 | 1.29 | 0.92–1.79 | 0.136 | 0 | HB | 4 | 0.97 | 0.77–1.21 | 0.550 | 52.2 | 0.92 | 0.69–1.22 | 0.554 | 57.3 | 1.20 | 0.74–1.94 | 0.466 | 0 | 0.84 | 0.72–1.23 | 0.643 | 58.1 | 1.20 | 0.74–1.94 | 0.456 | 0 | Location | | | | | | | | | | | | | | | | | | | | | | Gastric | 4 | 1.29 | 1.14–1.46 | <0.001 | 0 | 1.33 | 1.13–1.55 | <0.001 | 21.6 | 1.40 | 1.04–1.88 | 0.026 | 0 | 1.34 | 1.16–1.55 | <0.001 | 16 | 1.30 | 0.97–1.74 | 0.082 | 0 | Others | 3 | 0.91 | 0.70–1.18 | 0.472 | 57.4 | 0.88 | 0.62–1.24 | 0.460 | 69.2 | 1.02 | 0.50–2.08 | 0.962 | 0 | 0.89 | 0.64–1.22 | 0.461 | 66.7 | 1.04 | 0.51–2.13 | 0.905 | 0 |
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Numbers of comparisons.
aTest for heterogeneity.
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