TNF-Like Weak Inducer of Apoptosis Aggravates Left Ventricular Dysfunction after Myocardial Infarction in Mice

Figure 5

Genetic ablation of the Fn14 improves ventricular dysfunction and survival. (a) Genetic ablation of Fn14 in Fn14 −/− mice protected from progressive deterioration of left ventricular function after MI. Overall this resulted in improved survival after MI (𝑃=0.04; 𝑛=15 for each group for survival analysis). (b) Fn14 −/− mice also demonstrated reduced phosphorylation of p65. In addition upregulation of PGC-1α compared to wildtype littermates (Fn14 +/+) was also observed (𝑛=5 for Fn14 +/+ and 𝑛=6 for Fn14 −/− for molecular analysis).

(a)

(b)