Research Article
Role of TGF-β Pathway Polymorphisms in Sporadic Thoracic Aortic Aneurysm: rs900 TGF-β2 Is a Marker of Differential Gender Susceptibility
Table 3
Single nucleotide polymorphism frequencies of IL-10 pathway genes in patients affected by sporadic TAA and the two groups of controls subjects*.
| | SNPs | Genotypes | TAA patients
(%) | Control patients
(%) | Healthy controls
(%) |
| | rs1800896 | GG | 17 (11.8) |
7 (7.8) | 21 (12.5) | | GA | 66 (45.8) | 44 (48.9) | 67 (39.9) | | AA | 61 (42.4) | 39 (43.3) | 80 (47.6) |
| | rs1800871 | CC | 64 (44.4) | 45 (50.0) | 84 (50.0) | | CT |
65 (45.1) | 38 (42.2) | 67 (39.9) | | TT | 15 (10.5) |
7 (7.8) | 17 (10.1) |
| | rs1800872 | CC | 64 (44.4) | 45 (50.0) | 84 (50.0) | | CA | 65 (45.1) | 38 (42.2) | 67 (39.9) | | AA | 15 (10.5) |
7 (7.8) | 17 (10.1) |
| | rs3024496 | CC | 16 (11.1) |
5 (5.5) | 19 (11.3) | | CT | 66 (45.8) | 52 (57.8) | 69 (41.1) | | TT | 62 (43.1) | 33 (36.7) | 80 (47.6) |
| | rs2834167 | AA | 67 (46.6) | 35 (38.9) | 91 (54.2) | | AG | 66 (45.8) | 44 (48.9) | 60 (35.7) | | GG |
11 (7.6) | 11 (12.2) | 17 (10.1) |
|
|
No significant differences were found comparing TAA patient genotype frequencies with control patient and healthy control groups.
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