Role of TGF-β Pathway Polymorphisms in Sporadic Thoracic Aortic Aneurysm: rs900 TGF-β2 Is a Marker of Differential Gender Susceptibility

Table 5

Multiple logistic regression analyses of dominant (major allele homozygotes versus heterozygotes plus minor allele homozygotes) and recessive (major allele homozygotes plus heterozygotes versus minor allele homozygotes) models applied to TAA patient group compared with control groups.

SNP	Model	TAA versus control patients		TAA versus healthy controls
		OR (95% C.I.)	𝑃	OR (95% C.I.)	𝑃
rs1800471	Dominant	0.888 (0.452–1.858)	0.859	1.144 (0.630–2.075)	0.769
	Recessive	3.250 (0.290–36.392)	0.561	1.723 (0.154–19.210)	1.000
rs900	Dominant	0.550 (0.318–0.950)	0.036	0.520 (0.326–0.829)	0.0073
	Recessive	0.700 (0.348–1.407)	0.690	0.456 (0.242–0.859)	0.0177
rs334348	Dominant	1.074 (0.623–1.853)	0.889	1.035 (0.652–1.643)	0.906
	Recessive	1.265 (0.454–3.526)	0.791	0.460 (0.151–1.406)	0.181
rs334349	Dominant	1.093 (0.635–1.880)	0.782	0.858 (0.538–1.369)	0.553
	Recessive	0.546 (0.190–1.572)	0.329	0.511 (0.081–1.039)	0.0516
rs4522809	Dominant	0.917 (0.503–1.671)	0.878	0.939 (0.564–1.565)	0.897
	Recessive	0.954 (0.535–1.703)	1.000	0.758 (0.459–1.252)	0.307