Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents

Figure 5

Pretreatment effect on mice with naloxone (2 mg/kg, i.p.) in the antinociception induced by bufalin (0.6 mg/kg, i.p.) in the hot-plate test (a) and the first phase of formalin test (b). Data are expressed as the mean ± S.E.M. (𝑛=8), ^∗𝑃 < 0.05, ^∗∗𝑃 < 0.01, and ^∗∗∗𝑃 < 0.001, compared with the vehicle group.

(a)

(b)