Serum Matrix Metalloproteinase-3 as a Noninvasive Biomarker of Histological Synovitis for Diagnosis of Rheumatoid Arthritis

Table 3

Multiple linear regression analysis of variables associated with synovial MMP-3.

Variable	Unstandardized coefficients		Standardized coefficients	𝑡	𝑃	95% CI
	𝐵	Std. error
Components of synovitis score
Hyperplasia of lining layer	—	—	—	1.767	0.083	—
Inflammatory infiltration	—	—	—	0.361	0.719	—
Activation of synovial stroma	6.226	1.568	0.374	3.970	<0.001	3.086~9.366
Sublining inflammatory cells
CD3+ T cells	—	—	—	0.948	0.347	—
CD38+ plasma cells	—	—	—	0.528	0.599	—
CD68+ macrophages	0.006	0.002	0.284	3.016	0.004	0.002~0.009
CD15+ neutrophils	0.022	0.006	0.368	3.897	<0.001	0.011~0.033
Constant	26.071	2.645	—	9.857	<0.001	20.775~31.368