MSH Blunts Endotoxin-Induced MuRF1 and Atrogin-1 Upregulation in Skeletal Muscle by Modulating NF-B and Akt/FoxO1 Pathway
Figure 2
Effect of αMSH treatment (100 μg/kg) on serum concentration of corticosterone (a), ACTH (b), IGF-I (c), and IGFBP3 (d) in control rats or in rats treated with LPS (250 μg/kg). PF pair-fed rats. LPS administration increased the serum concentrations of corticosterone and ACTH , whereas αMSH had no significant effect either in control or LPS treated rats. Serum concentrations of IGF1 were decreased by LPS administration in both groups of rats treated with either αMSH or saline . LPS treatment decreased serum concentration of IGFBP3 . αMSH treatment prevented the effect of LPS on serum IGFBP3. Pair-feeding the rats did not modify serum corticosterone, ACTH, IGF-I, or IGFBP3 levels. Data are expressed as mean SEM for rats per group. ** and *, LSD multiple comparisons test.
