MSH Blunts Endotoxin-Induced MuRF1 and Atrogin-1 Upregulation in Skeletal Muscle by Modulating NF-B and Akt/FoxO1 Pathway

Figure 4

PhosphoNF-B(p65) (a), NF-B(p65) (b), phospho-Akt (c), and total-Akt (d) in gastrocnemius muscle of control, LPS and pair-fed (PF) rats treated with αMSH (100 μg/kg) or saline. LPS increased phosphoNF-B(p65) and decreased pAkt in the rats treated with saline but not in rats treated with MSH. Data represent mean SEM ( 7–10 rats). ** and *, LSD multiple comparisons test.