MSH Blunts Endotoxin-Induced MuRF1 and Atrogin-1 Upregulation in Skeletal Muscle by Modulating NF-B and Akt/FoxO1 Pathway
Figure 6
Atrogin-1 mRNA (a), MuRF1 mRNA (b), and MuRF1 (c) in gastrocnemius muscle of control, LPS and pair-fed (PF) rats treated with αMSH (100 μg/kg) or saline. LPS increased atrogin-1, MuRF1, and MuRF1 mRNA levels , and αMSH administration prevented those increases. Data represent mean SEM ( 7–10 rats). ** and *, LSD multiple comparison test.
