Lipoprotein Lipase and PPAR Alpha Gene Polymorphisms, Increased Very-Low-Density Lipoprotein Levels, and Decreased High-Density Lipoprotein Levels as Risk Markers for the Development of Visceral Leishmaniasis by Leishmania infantum
Table 4
Adjusted odds ratios (OR) and respective 95% confidence intervals for the association between levels of lipids (mg/dL) and genotypes of LPL, apoE, and PPAR and infected symptomatic and asymptomatic L. infantum infection.
Variable
Infected symptomatic infection
Infected asymptomatic infection
OR*
95% CI*
value
OR*
95% CI*
value
HindIII
H−/H−
1.00
1.00
H+/H−
6.37
0.84–83.4
0.083
2.04
0.49–10.4
0.435
H+/H+
21.3
2.32–335.3
0.003
3.48
0.72–20.4
0.143
PvuII
P1/P1
1.00
1.00
P1/P2
1.86
0.55–6.68
0.395
1.42
0.52–3.98
0.593
P2/P2
0.71
0.10–5.28
1.000
1.20
0.18–7.81
1.000
ApoE
E3/E4
1.00
1.00
E3/E3
2.66
0.52–16.1
0.312
0.91
0.28–2.93
1.000
E2/E3
4.31
0.23–113.7
0.515
1.90
0.22 –25.3
0.825
PPAR
Leu/Leu
1.00
1.00
Leu/Val
8.77
1.41–78.7
0.014
2.76
0.56–17.9
0.272
TC
0.99
0.97–1.01
0.301
1.00
0.99–1.01
0.787
LDL-C
0.99
0.97–1.01
0.353
1.01
0.99–1.02
0.414
HDL-C
0.84
0.71–0.96
0.006
0.92
0.84–0.99
0.027
TAG
1.02
1.00–1.03
0.021
1.00
0.99–1.01
0.597
VLDL-C
1.08
1.01–1.17
0.023
1.01
0.97–1.05
0.580
*Adjusted for age (≤ or >20 years) and gender. values in bold indicate statistically significant differences.
